GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs111803315 | 1 | rs1046701 | chr14:59939804 | JKAMP | chr14:59951161-59972080:+ | -0.18 | -3.41 | 0.000677 | Schizophrenia |
| BRCA | cis | rs1046896 | 1 | rs1046875 | chr17:80685426 | FN3K | chr17:80693452-80709073:+ | 0.15 | 4.66 | 3.58E-6 | Glycated hemoglobin levels |
| BRCA | cis | rs1046896 | 1 | rs1046875 | chr17:80685426 | FN3KRP | chr17:80674582-80685889:+ | 0.28 | 7.51 | 1.26E-13 | Glycated hemoglobin levels |
| BRCA | cis | rs1046896 | 1 | rs1046896 | chr17:80685533 | FN3K | chr17:80693452-80709073:+ | 0.16 | 4.87 | 1.31E-6 | Glycated hemoglobin levels |
| BRCA | cis | rs1046896 | 1 | rs1046896 | chr17:80685533 | FN3KRP | chr17:80674582-80685889:+ | 0.3 | 7.94 | 5.03E-15 | Glycated hemoglobin levels |
| BRCA | cis | rs1046896 | 1 | rs1046917 | chr17:80685655 | FN3K | chr17:80693452-80709073:+ | 0.15 | 4.65 | 3.8E-6 | Glycated hemoglobin levels |
| BRCA | cis | rs1046896 | 1 | rs1046917 | chr17:80685655 | FN3KRP | chr17:80674582-80685889:+ | 0.28 | 7.5 | 1.34E-13 | Glycated hemoglobin levels |
| BRCA | cis | rs9876781 | 1 | rs10470686 | chr3:48449956 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -10.46 | 1.91E-24 | Longevity |
| BRCA | cis | rs7267979 | 1 | rs1047171 | chr20:25428786 | FAM182A | chr20:26035250-26067552:+ | -0.23 | -6.12 | 1.31E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs1047171 | chr20:25428786 | FAM182B | chr20:25744102-25848786:- | 0.24 | 6.18 | 9.04E-10 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs1047171 | chr20:25428786 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.52 | 0.000454 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs6452524 | 1 | rs10474093 | chr5:82437431 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.46 | 0.000561 | Hypertension |
| BRCA | cis | rs7953704 | 1 | rs1047796 | chr12:122628219 | LRRC43 | chr12:122652266-122688017:+ | 0.16 | 4.56 | 5.79E-6 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs1047813 | chr12:122628516 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.82 | 1.63E-6 | Urate levels |
| BRCA | cis | rs10043228 | 1 | rs10478278 | chr5:115452758 | COMMD10 | chr5:115420727-115628978:+ | 0.2 | 4.36 | 1.45E-5 | Asthma or chronic obstructive pulmonary disease |